Study Validates Non-Contrast Enhanced MRA for Detecting Renal Artery Stenosis


Non-contrast enhanced MR angiography (MRA) techniques have attracted interest in the medical community for diagnosing renal artery stenosis, as it eliminates the need for gadolinium-based contrast agents used with CT angiography (CTA). In an international multi-center trial REACT (REnal Artery Contrast-free Trial), Canon Medical Systems’s Time-Spatial Labeling Inversion Pulse (Time-SLIP) is validated as a robust technique for non-contrast vascular imaging while providing an accurate and non-invasive method for diagnosing patients.

The results from the multi-center trial demonstrated the high sensitivity, specificity and diagnostic accuracy of Time-SLIP while also showing no statistical differences between non-contrast MRA and CTA in terms of their ability to visualize renal artery stenosis. The results from the trial were published in the January 2015 issue of American Journal of Roentgenology.

“Canon Medical Systems’s corporate philosophy is ‘Made for Life™,’ and it is one of our missions to minimize patients’ risk while providing exceptional images for their best possible medical treatment,” said Toshio Takiguchi, president, Canon Medical Systems Corporation (CMSC). “The REACT study has proved that it is now possible to detect renal artery stenosis without using contrast agents. Time-SLIP eliminates the need for gadolinium-based contrast agents, which results in safer and more comfortable examinations. Not only do these non-invasive and painless techniques eliminate the risks associated with gadolinium-based contrast agents, but they also require less setup time for clinicians, resulting in MR exams that are more comfortable for the patient and can be completed more quickly without compromising image quality.”

The trial consisted of 75 patients in collaboration with seven medical centers in five countries: the United States, Spain, China, France and Japan. All subjects underwent medically required non-contrast renal MRA exams, using the 1.5T Vantage AtlasTM and Vantage TitanTM MR systems, as well as CT angiography for the evaluation of renal artery stenosis.

“This is a first-of-its-kind multi-center, international, non-contrast vascular imaging trial,” said Dr. Timothy Albert, director, Cardiovascular Diagnostic Center at Salinas Valley Memorial Healthcare System, who served as the principal investigator of the trial. “It exemplifies the long-term commitment that Canon Medical Systems has to not only developing novel imaging solutions but providing clinical evidence to support them. REACT shows that Time-SLIP imaging can be user-friendly and applied to different patient groups. It works in diverse populations, from Asia to Europe and the United States.”

This article was originally published by Canon Medical Systems America Medical Systems in Tustin, Calif. on Jan. 8, 2015.

ABOUT Canon Medical Systems Canada Limited

Canon Medical Systems (CMSCA) provides patient-focused imaging technologies with specialties in CT, X-Ray, Ultrasound and MRI. Advanced service solutions range from single-room coverage to complete asset management programs.

Headquartered in Markham, Ontario, all sales, services and operations are Canadian-based, with a strong presence of technical service employees in more than 25 cities across the country. Reporting directly to Canon Medical Systems Corporation provides close ties to our research, engineering and product specialists, enabling the Canadian team to influence product decisions and delivery for the needs of our customers. For more information, visit the CMSCA website at www.Canon Medical

ABOUT Canon Medical Systems CORPORATION

Canon Medical Systems Corporation is a leading worldwide provider of medical diagnostic imaging systems and comprehensive medical solutions, such as CT, X-ray and vascular, ultrasound, nuclear medicine and MRI systems, as well as information systems for medical institutions. Canon Medical Systems Corporation has been providing medical products for 100 years. Visit Canon Medical Systems Corporation's website at www.Canon Medical


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